miR-31 from Mesenchymal Stem Cell-Derived Extracellular Vesicles Alleviates Intervertebral Disc Degeneration by Inhibiting NFAT5 and Upregulating the Wnt/β-Catenin Pathway

• Auteurs principaux: Baodong Wang (Auteur), Na Xu (Auteur), Li Cao (Auteur), Xiaojun Yu (Auteur), Shanxi Wang (Auteur), Qikun Liu (Auteur), Yinguang Wang (Auteur), Haoran Xu (Auteur), Yang Cao (Auteur)
• Format: Livre
• Publié: Hindawi Limited, 2022-01-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

In this study, we explored the regulatory mechanism of intervertebral disc degeneration (IDD) that involves miR-31 shuttled by bone marrow mesenchymal stem cell-derived extracellular vesicles (BMSC-EVs) and its downstream signaling molecules. Nucleus pulposus cells (NPCs) were isolated and treated w...