Icaritin inhibits the progression of urothelial cancer by suppressing PADI2-mediated neutrophil infiltration and neutrophil extracellular trap formation

• Main Authors: Zezhong Mou (Author), Yiling Chen (Author), Jinzhong Hu (Author), Yun Hu (Author), Lujia Zou (Author), Xinan Chen (Author), Shenghua Liu (Author), Qiuping Yin (Author), Jian Gong (Author), Shuchen Li (Author), Shanhua Mao (Author), Chenyang Xu (Author), Haowen Jiang (Author)
• Format: Book
• Published: Elsevier, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tumor relapse and metastasis are the major causes of mortality associated with urothelial cancer. In the tumor microenvironment, negative regulatory molecules and various immune cell subtypes suppress antitumor immunity. The inflammatory microenvironment, associated with neutrophils and neutrophil e...