Establishing a System for Testing Replication Inhibition of the Vibrio cholerae Secondary Chromosome in Escherichia coli

• Main Authors: Nadine Schallopp (Author), Sarah Milbredt (Author), Theodor Sperlea (Author), Franziska S. Kemter (Author), Matthias Bruhn (Author), Daniel Schindler (Author), Torsten Waldminghaus (Author)
• Format: Book
• Published: MDPI AG, 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Regulators of DNA replication in bacteria are an attractive target for new antibiotics, as not only is replication essential for cell viability, but its underlying mechanisms also differ from those operating in eukaryotes. The genetic information of most bacteria is encoded on a single chromosome, b...