Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway

• Main Authors: Xiangjin Zheng (Author), Wan Li (Author), Huanli Xu (Author), Jinyi Liu (Author), Liwen Ren (Author), Yihui Yang (Author), Sha Li (Author), Jinhua Wang (Author), Tengfei Ji (Author), Guanhua Du (Author)
• Format: Book
• Published: Elsevier, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glioblastoma multiforme (GBM) in the central nervous system is the most lethal advanced glioma and currently there is no effective treatment for it. Studies of sinomenine, an alkaloid from the Chinese medicinal plant, Sinomenium acutum, showed that it had inhibitory effects on several kinds of cance...