Specific Inhibition of CYP4A Alleviates Myocardial Oxidative Stress and Apoptosis Induced by Advanced Glycation End-Products

• Main Authors: Rui Wang (Author), Li Wang (Author), Jinlong He (Author), Shanshan Li (Author), Xiaojing Yang (Author), Pengyuan Sun (Author), Yuhui Yuan (Author), Jinyong Peng (Author), Jinsong Yan (Author), Jianling Du (Author), Hua Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

High exposure to advanced glycation end-products (AGEs) may induce cardiotoxicity. However, the effects and mechanisms remain to be further clarified. CYP4A plays an important role in the pathophysiological process of myocardial abnormalities by modulating oxidative stress and apoptosis (OS/Apop) si...