The biological function and clinical significance of SF3B1 mutations in cancer

• Main Authors: Zhixia Zhou (Author), Qi Gong (Author), Yin Wang (Author), Mengkun Li (Author), Lu Wang (Author), Hongfei Ding (Author), Peifeng Li (Author)
• Format: Book
• Published: BMC, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Spliceosome mutations have become the most interesting mutations detected in human cancer in recent years. The spliceosome, a large, dynamic multimegadalton small nuclear ribonucleoprotein composed of small nuclear RNAs associated with proteins, is responsible for removing introns from prec...