miR-342-5p downstream to Notch enhances arterialization of endothelial cells in response to shear stress by repressing MYC

• Main Authors: Xiaoyan Zhang (Author), Jiaxing Sun (Author), Peiran Zhang (Author), Ting Wen (Author), Ruonan Wang (Author), Liang Liang (Author), Ziyan Yang (Author), Jiayan Li (Author), Jiayulin Zhang (Author), Bo Che (Author), Xingxing Feng (Author), Xiaowei Liu (Author), Hua Han (Author), Xianchun Yan (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

During vascular development, endothelial cells (ECs) undergo arterialization in response to genetic programs and shear stress-triggered mechanotransduction, forming a stable vasculature. Although the Notch receptor is known to sense shear stress and promote EC arterialization, its downstream mechani...