H-Ferritin ferroxidase induces cytoprotective pathways and inhibits microvascular stasis in transgenic sickle mice

• প্রধান লেখক: Gregory M Vercellotti (লেখক), Fatima B Khan (লেখক), Heather eBechtel (লেখক), Karl A Nath (লেখক), Julia eNguyen (লেখক), Chunseng eChen (লেখক), Carol M Bruzzone (লেখক), Graham eBrown (লেখক), Clifford John Steer (লেখক), Robert P Hebbel (লেখক), John D. Belcher (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Frontiers Media S.A., 2014-04-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Hemolysis, oxidative stress, inflammation, vaso-occlusion and organ infarction are hallmarks of sickle cell disease (SCD). We have previously shown that increases in heme oxygenase-1 (HO-1) activity detoxify heme and inhibit vaso-occlusion in transgenic mouse models of SCD. HO-1 releases Fe2+ from h...