H-Ferritin ferroxidase induces cytoprotective pathways and inhibits microvascular stasis in transgenic sickle mice

• Main Authors: Gregory M Vercellotti (Author), Fatima B Khan (Author), Heather eBechtel (Author), Karl A Nath (Author), Julia eNguyen (Author), Chunseng eChen (Author), Carol M Bruzzone (Author), Graham eBrown (Author), Clifford John Steer (Author), Robert P Hebbel (Author), John D. Belcher (Author)
• Format: Book
• Published: Frontiers Media S.A., 2014-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hemolysis, oxidative stress, inflammation, vaso-occlusion and organ infarction are hallmarks of sickle cell disease (SCD). We have previously shown that increases in heme oxygenase-1 (HO-1) activity detoxify heme and inhibit vaso-occlusion in transgenic mouse models of SCD. HO-1 releases Fe2+ from h...