A hypothermia mimetic molecule (zr17-2) reduces ganglion cell death, gliosis, and electroretinogram distortion in male rats subjected to perinatal asphyxia

• Main Authors: Manuel Rey-Funes (Author), Juan Carlos Fernández (Author), Rafael Peláez (Author), Manuel Soliño (Author), Daniela S. Contartese (Author), Nicolás S. Ciranna (Author), Ronan Nakamura (Author), Aníbal Sarotto (Author), Verónica B. Dorfman (Author), José M. Zapico (Author), Ana Ramos (Author), Beatriz de Pascual-Teresa (Author), Juan José López-Costa (Author), Ignacio M. Larrayoz (Author), Alfredo Martínez (Author), César Fabián Loidl (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Perinatal asphyxia (PA) represents a major problem in perinatology and may cause visual losses, including blindness. We, and others, have shown that hypothermia prevents retinal symptoms associated to PA. In the present work, we evaluate whether a hypothermia mimetic small molecule, zr...