TGF-β mediates early angiogenesis and latent fibrosis in an Emilin1-deficient mouse model of aortic valve disease

• Main Authors: Charu Munjal (Author), Amy M. Opoka (Author), Hanna Osinska (Author), Jeanne F. James (Author), Giorgio M. Bressan (Author), Robert B. Hinton (Author)
• Format: Book
• Published: The Company of Biologists, 2014-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aortic valve disease (AVD) is characterized by elastic fiber fragmentation (EFF), fibrosis and aberrant angiogenesis. Emilin1 is an elastin-binding glycoprotein that regulates elastogenesis and inhibits TGF-β signaling, but the role of Emilin1 in valve tissue is unknown. We tested the hypothesis tha...