RhoA/ROCK2 signalling is enhanced by PDGF‐AA in fibro‐adipogenic progenitor cells: implications for Duchenne muscular dystrophy

• Main Authors: Esther Fernández‐Simón (Author), Xavier Suárez‐Calvet (Author), Ana Carrasco‐Rozas (Author), Patricia Piñol‐Jurado (Author), Susana López‐Fernández (Author), Gemma Pons (Author), Joan Josep Bech Serra (Author), Carolina de laTorre (Author), Noemí deLuna (Author), Eduard Gallardo (Author), Jordi Díaz‐Manera (Author)
• Format: Book
• Published: Wiley, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The lack of dystrophin expression in Duchenne muscular dystrophy (DMD) induces muscle fibre and replacement by fibro‐adipose tissue. Although the role of some growth factors in the process of fibrogenesis has been studied, pathways activated by PDGF‐AA have not been described so...