Modulating retinoid-X-receptor alpha (RXRA) expression sensitizes chronic myeloid leukemia cells to imatinib in vitro and reduces disease burden in vivo

• Main Authors: Bharathi M. Rajamani (Author), Raveen Stephen Stallon Illangeswaran (Author), Esther Sathya Bama Benjamin (Author), Balaji Balakrishnan (Author), Daniel Zechariah Paul Jebanesan (Author), Saswati Das (Author), Aswin Anand Pai (Author), Rakhi Thalayattu Vidhyadharan (Author), Ajith Mohan (Author), Sreeja Karathedath (Author), Aby Abraham (Author), Vikram Mathews (Author), Shaji R. Velayudhan (Author), Poonkuzhali Balasubramanian (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: The ligand-activated transcription factors, nuclear hormone receptors (NHRs), remain unexplored in hematological malignancies except for retinoic acid receptor alpha (RARA).Methods: Here we profiled the expression of various NHRs and their coregulators in Chronic myeloid leukemia (CML)...