Antihyperalgesic Effect of Buprenorphine Involves Nociceptin/Orphanin FQ Peptide-Receptor Activation in Rats With Spinal Nerve Injury-Induced Neuropathy

• Main Authors: Tomoko Takahashi (Author), Kazumasa Okubo (Author), Shota Kojima (Author), Hiroyuki Nishikawa (Author), Motohide Takemura (Author), Maho Tsubota-Matsunami (Author), Fumiko Sekiguchi (Author), Atsufumi Kawabata (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: We evaluated the effect of buprenorphine, a mixed agonist for μ-opioid receptors and nociceptin/orphanin FQ peptide (NOP) receptors, in neuropathic rats, using the paw pressure test. Buprenorphine, administered i.p. at 50, but not 20, μg/kg, exhibited naloxone-reversible analgesic activit...