Proteomic analysis of the action of the Mycobacterium ulcerans toxin mycolactone: targeting host cells cytoskeleton and collagen.

• Main Authors: José B Gama (Author), Steffen Ohlmeier (Author), Teresa G Martins (Author), Alexandra G Fraga (Author), Belém Sampaio-Marques (Author), Maria A Carvalho (Author), Fernanda Proença (Author), Manuel T Silva (Author), Jorge Pedrosa (Author), Paula Ludovico (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Buruli ulcer (BU) is a neglected tropical disease caused by Mycobacterium ulcerans. The tissue damage characteristic of BU lesions is known to be driven by the secretion of the potent lipidic exotoxin mycolactone. However, the molecular action of mycolactone on host cell biology mediating cytopathog...