All-trans retinoic acid suppresses the adhering ability of ARPE-19 cells via mitogen-activated protein kinase and focal adhesion kinase

• Main Authors: Yo-Chen Chang (Author), Yuh-Shin Chang (Author), Ming-Chu Hsieh (Author), Horng-Jiun Wu (Author), Meng-Hsien Wu (Author), Chia-Wei Lin (Author), Wen-Chuan Wu (Author), Ying-Hsien Kao (Author)
• Format: Book
• Published: Elsevier, 2016-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study investigated the signaling mechanism underlying the anti-adhesive effect of all-trans retinoic acid (ATRA) on retinal pigment epithelial ARPE-19 cells. Adhesion kinetics with or without ATRA treatment were profiled by adhesion assay. Surface coating with type IV collagen, fibronectin, lam...