The Effect of Biorelevant Hydrodynamic Conditions on Drug Dissolution from Extended-Release Tablets in the Dynamic Colon Model

• Главные авторы: Connor O'Farrell (Автор), Mark J. H. Simmons (Автор), Hannah K. Batchelor (Автор), Konstantinos Stamatopoulos (Автор)
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• Опубликовано: MDPI AG, 2022-10-01T00:00:00Z.
• Предметы: article
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The in vitro release of theophylline from an extended-release dosage form was studied under different hydrodynamic conditions in a United States Pharmacopoeial (USP) dissolution system II and a bespoke in vitro tubular model of the human colon, the Dynamic Colon Model (DCM). Five biorelevant motilit...