Dimerization and lysine substitution of melittin have differing effects on bacteria

• Главные авторы: Tamara Matthyssen (Автор), Wenyi Li (Автор), James A. Holden (Автор), Jason C. Lenzo (Автор), Sara Hadjigol (Автор), Neil M. O'Brien-Simpson (Автор)
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• Опубликовано: Frontiers Media S.A., 2024-10-01T00:00:00Z.
• Предметы: article
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IntroductionMelittin is a potent antimicrobial peptide from bee venom that is effective against both Gram-positive and Gram-negative bacteria. However, it is extremely toxic to mammalian cells and, as yet, has no clinical use. Modifications to its amino acid sequence, cyclization, truncation, and di...