Dimerization and lysine substitution of melittin have differing effects on bacteria

• Main Authors: Tamara Matthyssen (Author), Wenyi Li (Author), James A. Holden (Author), Jason C. Lenzo (Author), Sara Hadjigol (Author), Neil M. O'Brien-Simpson (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IntroductionMelittin is a potent antimicrobial peptide from bee venom that is effective against both Gram-positive and Gram-negative bacteria. However, it is extremely toxic to mammalian cells and, as yet, has no clinical use. Modifications to its amino acid sequence, cyclization, truncation, and di...