Leveraging large observational studies to discover genetic determinants of drug concentrations: A proof‐of‐concept study

• Main Authors: Maxime Meloche (Author), Grégoire Leclair (Author), Martin Jutras (Author), Essaïd Oussaïd (Author), Marie‐Josée Gaulin (Author), Ian Mongrain (Author), David Busseuil (Author), Jean‐Claude Tardif (Author), Marie‐Pierre Dubé (Author), Simon deDenus (Author)
• Format: Book
• Published: Wiley, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Large, observational genetic studies are commonly used to identify genetic factors associated with diseases and disease‐related traits. Such cohorts have not been commonly used to identify genetic predictors of drug dosing or concentrations, perhaps because of the heterogeneity in drug dosi...