SOX4 Mediates BRAF Inhibitor Resistance in Melanoma through Regulation of IGF-1R Signaling: In Vitro Study

• Main Authors: Xiao Liu (Author), Jun Mi (Author), Hai-Hong Qin (Author), Shan He (Author), Zheng Li (Author), Jing-Xiu Chai (Author), Ming Li (Author), Jin-Hua Xu (Author), Jin-Feng Wu (Author)
• Format: Book
• Published: Wolters Kluwer Health, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract. Objective:. SOX4, a transcription factor, has been found to contribute to tumorigenesis in several cancers. This study was performed to determine whether SOX4 mediates BRAF inhibitor resistance in melanoma. Methods:. Melanoma cell lines with acquired resistance to BRAF inhibitor (SK-MEL-5R...