SOX4 Mediates BRAF Inhibitor Resistance in Melanoma through Regulation of IGF-1R Signaling: In Vitro Study

• Hoofdauteurs: Xiao Liu (Auteur), Jun Mi (Auteur), Hai-Hong Qin (Auteur), Shan He (Auteur), Zheng Li (Auteur), Jing-Xiu Chai (Auteur), Ming Li (Auteur), Jin-Hua Xu (Auteur), Jin-Feng Wu (Auteur)
• Formaat: Boek
• Gepubliceerd in: Wolters Kluwer Health, 2020-09-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Abstract. Objective:. SOX4, a transcription factor, has been found to contribute to tumorigenesis in several cancers. This study was performed to determine whether SOX4 mediates BRAF inhibitor resistance in melanoma. Methods:. Melanoma cell lines with acquired resistance to BRAF inhibitor (SK-MEL-5R...