Administration of E2 and NS1 siRNAs inhibit chikungunya virus replication in vitro and protects mice infected with the virus.

• Main Authors: Deepti Parashar (Author), Mandar S Paingankar (Author), Satyendra Kumar (Author), Mangesh D Gokhale (Author), A B Sudeep (Author), Sapana B Shinde (Author), V A Arankalle (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>Chikungunya virus (CHIKV) has reemerged as a life threatening pathogen and caused large epidemics in several countries. So far, no licensed vaccine or effective antivirals are available and the treatment remains symptomatic. In this context, development of effective an...