Radioligands for Tropomyosin Receptor Kinase (Trk) Positron Emission Tomography Imaging

• Main Authors: Ralf Schirrmacher (Author), Justin J. Bailey (Author), Andrew V. Mossine (Author), Peter J. H. Scott (Author), Lena Kaiser (Author), Peter Bartenstein (Author), Simon Lindner (Author), David R. Kaplan (Author), Alexey Kostikov (Author), Gert Fricker (Author), Anne Mahringer (Author), Pedro Rosa-Neto (Author), Esther Schirrmacher (Author), Carmen Wängler (Author), Björn Wängler (Author), Alexander Thiel (Author), Jean-Paul Soucy (Author), Vadim Bernard-Gauthier (Author)
• Format: Book
• Published: MDPI AG, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The tropomyosin receptor kinases family (TrkA, TrkB, and TrkC) supports neuronal growth, survival, and differentiation during development, adult life, and aging. TrkA/B/C downregulation is a prominent hallmark of various neurological disorders including Alzheimer’s disease (AD). Abnormally expressed...