Targeting and pharmacology of an anti-IL13Rα2 antibody and antibody-drug conjugate in a melanoma xenograft model

• Главные авторы: Parul Gupta (Автор), Ziyue Karen Jiang (Автор), Bing Yang (Автор), Lisa Manzuk (Автор), Edward Rosfjord (Автор), Johnny Yao (Автор), Luanna Lemon (Автор), Kavon Noorbehesht (Автор), John David (Автор), Sujiet Puthenveetil (Автор), Jeffrey M. Casavant (Автор), Elwira Muszynska (Автор), Fengping Li (Автор), Mauricio Leal (Автор), Puja Sapra (Автор), Anand Giddabasappa (Автор)
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• Опубликовано: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Предметы: article
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IL13Rα2 is a cell surface tumor antigen that is overexpressed in multiple tumor types. Here, we studied biodistribution and targeting potential of an anti-IL13Rα2 antibody (Ab) and anti-tumor activity of anti-IL13Rα2-antibody-drug conjugate (ADC). The anti-IL13Rα2 Ab was labeled with fluorophore AF6...