Targeting and pharmacology of an anti-IL13Rα2 antibody and antibody-drug conjugate in a melanoma xenograft model

• Main Authors: Parul Gupta (Author), Ziyue Karen Jiang (Author), Bing Yang (Author), Lisa Manzuk (Author), Edward Rosfjord (Author), Johnny Yao (Author), Luanna Lemon (Author), Kavon Noorbehesht (Author), John David (Author), Sujiet Puthenveetil (Author), Jeffrey M. Casavant (Author), Elwira Muszynska (Author), Fengping Li (Author), Mauricio Leal (Author), Puja Sapra (Author), Anand Giddabasappa (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IL13Rα2 is a cell surface tumor antigen that is overexpressed in multiple tumor types. Here, we studied biodistribution and targeting potential of an anti-IL13Rα2 antibody (Ab) and anti-tumor activity of anti-IL13Rα2-antibody-drug conjugate (ADC). The anti-IL13Rα2 Ab was labeled with fluorophore AF6...