3,3'-diindolylmethane inhibits LPS-induced human chondrocytes apoptosis and extracellular matrix degradation by activating PI3K-Akt-mTOR-mediated autophagy

• Autors principals: Hao Tang (Autor), Kunpeng Qin (Autor), Anquan Wang (Autor), Shuang Li (Autor), Sheng Fang (Autor), Weilu Gao (Autor), Ming Lu (Autor), Wei Huang (Autor), Hui Zhang (Autor), Zongsheng Yin (Autor)
• Format: Llibre
• Publicat: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Osteoarthritis (OA) is a chronic degenerative joint disease characterized by articular cartilage destruction. The pathological mechanisms are complex; in particular, inflammation, autophagy, and apoptosis are often involved. 3,3-Diindolylmethane (DIM), a phytoconstituent extracted from cruciferous v...