3,3'-diindolylmethane inhibits LPS-induced human chondrocytes apoptosis and extracellular matrix degradation by activating PI3K-Akt-mTOR-mediated autophagy

• Main Authors: Hao Tang (Author), Kunpeng Qin (Author), Anquan Wang (Author), Shuang Li (Author), Sheng Fang (Author), Weilu Gao (Author), Ming Lu (Author), Wei Huang (Author), Hui Zhang (Author), Zongsheng Yin (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Osteoarthritis (OA) is a chronic degenerative joint disease characterized by articular cartilage destruction. The pathological mechanisms are complex; in particular, inflammation, autophagy, and apoptosis are often involved. 3,3-Diindolylmethane (DIM), a phytoconstituent extracted from cruciferous v...