Comparative AAV-eGFP Transgene Expression Using Vector Serotypes 1-9, 7m8, and 8b in Human Pluripotent Stem Cells, RPEs, and Human and Rat Cortical Neurons

• Main Authors: Thu T. Duong (Author), James Lim (Author), Vidyullatha Vasireddy (Author), Tyler Papp (Author), Hung Nguyen (Author), Lanfranco Leo (Author), Jieyan Pan (Author), Shangzhen Zhou (Author), H. Isaac Chen (Author), Jean Bennett (Author), Jason A. Mills (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recombinant adeno-associated virus (rAAV), produced from a nonpathogenic parvovirus, has become an increasing popular vector for gene therapy applications in human clinical trials. However, transduction and transgene expression of rAAVs can differ across in vitro and ex vivo cellular transduction st...