Design, synthesis, and biological investigation of oxadiazolyl, thiadiazolyl, and pyrimidinyl linked antipyrine derivatives as potential non-acidic anti-inflammatory agents

• Main Authors: Mohammad M. Al-Sanea (Author), Abdelrahman Hamdi (Author), Simone Brogi (Author), Samar S. Tawfik (Author), Dina I. A. Othman (Author), Mahmoud Elshal (Author), Hidayat Ur Rahman (Author), Della G. T. Parambi (Author), Rehab M. Elbargisy (Author), Samy Selim (Author), Ehab M. Mostafa (Author), Ahmed A. B. Mohamed (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A novel series of 12 antipyrine derivatives containing 1,3,4-oxadiazoles (4a-d), 1,3,4-thiadiazoles (6a-d), and pyrimidines (8a-d), was preparedand assessed for its potential in vitro COX-2 inhibitors. Compared to Celecoxib, compounds 4b-d and 8d were the most potent derivatives c with a half-maxima...