Evaluation of pharmacokinetics and relative bioavailability of pentoxifylline and its metabolite in beagle dogs following different formulations

• Main Authors: Yuxiang Xu (Author), Hongxin Qie (Author), Haopeng Zhao (Author), Wenlin Gong (Author), Peiyuan Wang (Author), Xiaonan Gao (Author), Jinglin Gao (Author), Zhangying Feng (Author), Mingxia Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A single-oral-dose, two-period cross-over study with a 5-day washout period under fed condition was conducted in six beagle dogs to explore the pharmacokinetic characteristics and relative bioavailability between sustained-release (SR) tablets and enteric-coated (EC) tablets of pentoxifylline (PTX)...