Exome-wide analysis of copy number variation shows association of the human leukocyte antigen region with asthma in UK Biobank

• Main Authors: Katherine A. Fawcett (Author), German Demidov (Author), Nick Shrine (Author), Megan L. Paynton (Author), Stephan Ossowski (Author), Ian Sayers (Author), Louise V. Wain (Author), Edward J. Hollox (Author)
• Format: Book
• Published: BMC, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The role of copy number variants (CNVs) in susceptibility to asthma is not well understood. This is, in part, due to the difficulty of accurately measuring CNVs in large enough sample sizes to detect associations. The recent availability of whole-exome sequencing (WES) in large b...