Improvement of Neurodegenerative Disease after Use of Vemurafenib in Refractory BRAF V600E-Mutated Langerhans Cell Histiocytosis: A Case Report

• Main Authors: Young Kwon Koh (Author), Su Hyun Yoon (Author), Sung Han Kang (Author), Hyery Kim (Author), Ho Joon Im (Author), Pyeong Hwa Kim (Author), Ah Young Jung (Author), Kyung-Nam Koh (Author)
• Format: Book
• Published: The Korean Society of Pediatric Hematology-Oncology, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Langerhans cell histiocytosis (LCH) is a rare histiocytic disorder characterized by heterogenous lesions infiltrated with CD1a+/CD207+ cells. Although LCH has a relatively good prognosis, the prognosis for patients with LCH refractory to standard chemotherapy is poor. Neurodegenerative LCH (ND-LCH)...