Optimized self-microemulsifying drug delivery system improves the oral bioavailability and brain delivery of coenzyme Q10

• Main Authors: Thapa Chhitij (Author), Jo-Eun Seo (Author), Taekwang Keum (Author), Gyubin Noh (Author), Santosh Bashyal (Author), Shrawani Lamichhane (Author), Jung Hwan Kim (Author), Jae Heon Lee (Author), Jee Hun Park (Author), Jaewoong Choi (Author), Se Hyun Song (Author), Sangkil Lee (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Our study aimed to develop a self-microemulsifying drug delivery system for the poorly aqueous-soluble drug Coenzyme Q10, to improve the dissolution and the oral bioavailability. Excipients were selected based on their Coenzyme Q10 solubility, and their concentrations were set for the optimization o...