Lentiviral vectors transduce lung stem cells without disrupting plasticity

Life-long expression of a gene therapy agent likely requires targeting stem cells. Here we ask the question: does viral vector transduction or ectopic expression of a therapeutic transgene preclude airway stem cell function? We used a lentiviral vector containing a GFP or cystic fibrosis transmembra...

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Bibliographic Details
Main Authors: Ashley L. Cooney (Author), Andrew L. Thurman (Author), Paul B. McCray, Jr (Author), Alejandro A. Pezzulo (Author), Patrick L. Sinn (Author)
Format: Book
Published: Elsevier, 2021-09-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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