Dual Antitubercular and Antileishmanial Profiles of Quinoxaline Di-<i>N</i>-Oxides Containing an Amino Acidic Side Chain

• Main Authors: Juan F. González (Author), María-Auxiliado (Author), Lena Huck (Author), José María Orduña (Author), Francisco Bolás-Fernández (Author), Elena de la Cuesta (Author), Nazia Haseen (Author), Ashraf Ali Mohammed (Author), J. Carlos Menéndez (Author)
• Format: Book
• Published: MDPI AG, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We present a new category of quinoxaline di-N-oxides (QdNOs) containing amino acid side chains with dual antituberculosis and antileishmanial activity. These compounds were synthesized by combining a regioselective 2,5-piperazinedione opening and a Beirut reaction and were screened for their activit...