Copper-induced diurnal hepatic toxicity is associated with Cry2 and Per1 in mice

• Main Authors: Sarah Tominaga (Author), Hiroki Yoshioka (Author), Satoshi Yokota (Author), Yosuke Tsukiboshi (Author), Masumi Suzui (Author), Makoto Nagai (Author), Hirokazu Hara (Author), Tohru Maeda (Author), Nobuhiko Miura (Author)
• Format: Book
• Published: Komiyama Printing Co. Ltd, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: This study aimed to investigate diurnal variations in copper-induced hepatic toxicity and the molecular mechanisms underlying this chronotoxicity. Methods: Male C57BL/6J mice were intraperitoneally injected with copper chloride (CuCl2) at zeitgeber time 2 (ZT2) or 14 (ZT14), twice per we...