CDR3 Variants of the TXB2 Shuttle with Increased TfR1 Association Rate and Enhanced Brain Penetration

• Main Authors: Pawel Stocki (Author), Jaroslaw Szary (Author), Mykhaylo Demydchuk (Author), Leandra Northall (Author), Charlotte L. M. Rasmussen (Author), Diana Bahu Logan (Author), Aziz Gauhar (Author), Laura Thei (Author), Shu-Fen Coker (Author), Torben Moos (Author), Frank S. Walsh (Author), J. Lynn Rutkowski (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Since the delivery of biologic drugs to the brain is greatly hampered by the existence of the blood-brain barrier (BBB), brain shuttles are being developed to enhance therapeutic efficacy. As we have previously shown, efficient and selective brain delivery was achieved with TXB2, a cross-species rea...