HDAC Inhibition Regulates Cardiac Function by Increasing Myofilament Calcium Sensitivity and Decreasing Diastolic Tension

• Main Authors: Deborah M. Eaton (Author), Thomas G. Martin (Author), Michael Kasa (Author), Natasa Djalinac (Author), Senka Ljubojevic-Holzer (Author), Dirk Von Lewinski (Author), Maria Pöttler (Author), Theerachat Kampaengsri (Author), Andreas Krumphuber (Author), Katharina Scharer (Author), Heinrich Maechler (Author), Andreas Zirlik (Author), Timothy A. McKinsey (Author), Jonathan A. Kirk (Author), Steven R. Houser (Author), Peter P. Rainer (Author), Markus Wallner (Author)
• 格式: 图书
• 出版: MDPI AG, 2022-07-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

We recently established a large animal model that recapitulates key clinical features of heart failure with preserved ejection fraction (HFpEF) and tested the effects of the pan-HDAC inhibitor suberoylanilide hydroxamic acid (SAHA). SAHA reversed and prevented the development of cardiopulmonary impa...