Structural Changes Due to Antagonist Binding in Ligand Binding Pocket of Androgen Receptor Elucidated Through Molecular Dynamics Simulations

• 主要な著者: Sugunadevi Sakkiah (著者), Rebecca Kusko (著者), Bohu Pan (著者), Wenjing Guo (著者), Weigong Ge (著者), Weida Tong (著者), Huixiao Hong (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2018-05-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

When a small molecule binds to the androgen receptor (AR), a conformational change can occur which impacts subsequent binding of co-regulator proteins and DNA. In order to accurately study this mechanism, the scientific community needs a crystal structure of the Wild type AR (WT-AR) ligand binding d...