Incomplete Suppression of HIV-1 by SAMHD1 Permits Efficient Macrophage Infection

• Váldodahkkit: Timothy Plitnik (Dahkki), Mark E. Sharkey (Dahkki), Bijan Mahboubi (Dahkki), Baek Kim (Dahkki), Mario Stevenson (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Case Western Reserve University, 2018-12-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Background: Sterile alpha motif and histidine/aspartic acid domain-containing protein (SAMHD1) is a dNTP triphosphorylase that reduces cellular dNTP levels in non-dividing cells, such as macrophages. Since dNTPs are required for reverse transcription, HIV-2 and most SIVs encode a Vpx protein that pr...