Incomplete Suppression of HIV-1 by SAMHD1 Permits Efficient Macrophage Infection

• Main Authors: Timothy Plitnik (Author), Mark E. Sharkey (Author), Bijan Mahboubi (Author), Baek Kim (Author), Mario Stevenson (Author)
• Format: Book
• Published: Case Western Reserve University, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Sterile alpha motif and histidine/aspartic acid domain-containing protein (SAMHD1) is a dNTP triphosphorylase that reduces cellular dNTP levels in non-dividing cells, such as macrophages. Since dNTPs are required for reverse transcription, HIV-2 and most SIVs encode a Vpx protein that pr...