Epigenetic drug library screening reveals targeting DOT1L abrogates NAD+ synthesis by reprogramming H3K79 methylation in uveal melanoma

• Váldodahkkit: Xiang Gu (Dahkki), Yu Hua (Dahkki), Jie Yu (Dahkki), Ludi Yang (Dahkki), Shengfang Ge (Dahkki), Renbing Jia (Dahkki), Peiwei Chai (Dahkki), Ai Zhuang (Dahkki), Xianqun Fan (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Elsevier, 2023-01-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Uveal melanoma (UM) is the most frequent and life-threatening ocular malignancy in adults. Aberrant histone methylation contributes to the abnormal transcriptome during oncogenesis. However, a comprehensive understanding of histone methylation patterns and their therapeutic potential in UM remains e...