Epigenetic drug library screening reveals targeting DOT1L abrogates NAD+ synthesis by reprogramming H3K79 methylation in uveal melanoma

• Main Authors: Xiang Gu (Author), Yu Hua (Author), Jie Yu (Author), Ludi Yang (Author), Shengfang Ge (Author), Renbing Jia (Author), Peiwei Chai (Author), Ai Zhuang (Author), Xianqun Fan (Author)
• Format: Book
• Published: Elsevier, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Uveal melanoma (UM) is the most frequent and life-threatening ocular malignancy in adults. Aberrant histone methylation contributes to the abnormal transcriptome during oncogenesis. However, a comprehensive understanding of histone methylation patterns and their therapeutic potential in UM remains e...