Effect of metformin on the neuronal morphology of frontal cortex and hippocampal regions in lipopolysaccharide induced neuroinflammation in male Wistar rats

• Main Authors: Vandana Blossom (Author), Sheetal D. Ullal (Author), Rajalakshmi Rai (Author), Amit Massand (Author), Chettiar Ganesh Kumar (Author), Teresa Joy (Author), Melisha Michael D souza (Author), B.V. Murlimanju (Author)
• Format: Book
• Published: Elsevier, 2025-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Neuroinflammation in the frontal cortex and hippocampus is the key contributor in the pathogenesis of neurodegenerative diseases. Lipopolysaccharide (LPS) is a bacterial endotoxin (E-coli phenol extract) used to induce the neuroinflammation in animal models. Our study is aimed to study t...