Decoding the mannose receptor-mAb interaction: the importance of high-mannose N-glycans and glycan-pairing

• Main Authors: Julia Baumeister (Author), Maximilian Meudt (Author), Sybille Ebert (Author), Frank Rosenau (Author), Boris Mizaikoff (Author), Michaela Blech (Author), Kristina M. J. Aertker (Author), Fabian Higel (Author)
• Formato: Livro
• Publicado em: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

During the development process of therapeutic monoclonal antibodies (mAbs), it is crucial to control (critical) quality attributes such as N-glycosylation influencing pharmacokinetics (PK) and Fc effector functions. Previous reports have shown that mAbs containing high-mannose N-glycans are cleared...