Down-regulation of DNA key protein-FEN1 inhibits OSCC growth by affecting immunosuppressive phenotypes via IFN-γ/JAK/STAT-1

• Main Authors: Shimeng Wang (Author), Xiangjian Wang (Author), Jun Sun (Author), Jin Yang (Author), Deyang Wu (Author), Fanglong Wu (Author), Hongmei Zhou (Author)
• Format: Book
• Published: Nature Publishing Group, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Oral squamous cell carcinoma (OSCC) escape from the immune system is mediated through several immunosuppressive phenotypes that are critical to the initiation and progression of tumors. As a hallmark of cancer, DNA damage repair is closely related to changes in the immunophenotypes of tumor...