Deficiency of the bone mineralization inhibitor NPP1 protects mice against obesity and diabetes

• Main Authors: Carmen Huesa (Author), Dongxing Zhu (Author), James D. Glover (Author), Mathieu Ferron (Author), Gerard Karsenty (Author), Elspeth M. Milne (Author), José Luis Millan (Author), S. Faisal Ahmed (Author), Colin Farquharson (Author), Nicholas M. Morton (Author), Vicky E. MacRae (Author)
• Format: Book
• Published: The Company of Biologists, 2014-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The emergence of bone as an endocrine regulator has prompted a re-evaluation of the role of bone mineralization factors in the development of metabolic disease. Ectonucleotide pyrophosphatase/phosphodiesterase-1 (NPP1) controls bone mineralization through the generation of pyrophosphate, and levels...