Deficiency of the bone mineralization inhibitor NPP1 protects mice against obesity and diabetes

• المؤلفون الرئيسيون: Carmen Huesa (مؤلف), Dongxing Zhu (مؤلف), James D. Glover (مؤلف), Mathieu Ferron (مؤلف), Gerard Karsenty (مؤلف), Elspeth M. Milne (مؤلف), José Luis Millan (مؤلف), S. Faisal Ahmed (مؤلف), Colin Farquharson (مؤلف), Nicholas M. Morton (مؤلف), Vicky E. MacRae (مؤلف)
• التنسيق: كتاب
• منشور في: The Company of Biologists, 2014-12-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

The emergence of bone as an endocrine regulator has prompted a re-evaluation of the role of bone mineralization factors in the development of metabolic disease. Ectonucleotide pyrophosphatase/phosphodiesterase-1 (NPP1) controls bone mineralization through the generation of pyrophosphate, and levels...