Dipyridamole activates adenosine A2B receptor and AMPK/cAMP signaling and promotes myogenic differentiation of myoblastic C2C12 cells

• Main Authors: Miguel Marco-Bonilla (Author), Raquel Herencia (Author), María Fresnadillo (Author), Fernando Huete-Toral (Author), Gonzalo Carracedo (Author), Raquel Largo (Author), Gabriel Herrero-Beaumont (Author), Aránzazu Mediero (Author)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2023-09-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Introduction: Sarcopenia is defined as a loss of muscle mass and strength. ATP homeostasis is crucial during myogenesis. We determined how the purinergic system modulates myogenesis using dipyridamole (blocks adenosine taken up by the cells) and tenofovir (inhibits ATP release) in a myoblast cell li...