Four-Octyl itaconate ameliorates periodontal destruction via Nrf2-dependent antioxidant system

• Main Authors: Liangjing Xin (Author), Fuyuan Zhou (Author), Chuangwei Zhang (Author), Wenjie Zhong (Author), Shihan Xu (Author), Xuan Jing (Author), Dong Wang (Author), Si Wang (Author), Tao Chen (Author), Jinlin Song (Author)
• Format: Book
• Published: Nature Publishing Group, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Periodontitis is a widespread oral disease characterized by continuous inflammation of the periodontal tissue and an irreversible alveolar bone loss, which eventually leads to tooth loss. Four-octyl itaconate (4-OI) is a cell-permeable itaconate derivative and has been recognized as a promi...