IDH2 regulates macrophage polarization and tumorigenesis by modulating mitochondrial metabolism in macrophages

• Main Authors: Sung Woo Lee (Author), Soyoon Kim (Author), Bokyung Kim (Author), Jung Bae Seong (Author), Young-Ho Park (Author), Hong Jun Lee (Author), Dong Kyu Choi (Author), Eunbyul Yeom (Author), Dong-Seok Lee (Author)
• Format: Book
• Published: BMC, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Targeting the tumor microenvironment represents an emerging therapeutic strategy for cancer. Macrophages are an essential part of the tumor microenvironment. Macrophage polarization is modulated by mitochondrial metabolism, including oxidative phosphorylation (OXPHOS), the tricar...