Variants in <i>COMT</i>, <i>CYP3A5</i>, <i>CYP2B6,</i> and <i>ABCG2</i> Alter Quetiapine Pharmacokinetics

• Egile Nagusiak: Pablo Zubiaur (Egilea), Paula Fernández-Campos (Egilea), Marcos Navares-Gómez (Egilea), Paula Soria-Chacartegui (Egilea), Gonzalo Villapalos-García (Egilea), Manuel Román (Egilea), Gina Mejía-Abril (Egilea), Dolores Ochoa (Egilea), Francisco Abad-Santos (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2021-09-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Quetiapine is an atypical antipsychotic widely used for the treatment of schizophrenia and the depressive episodes of bipolar disorder. The aim of this work was to investigate the effect of variants in relevant pharmacogenes in the pharmacokinetics of quetiapine and to exploratorily evaluate adverse...