Angiotensin II type 1 receptor autoantibody blockade improves cerebral blood flow autoregulation and hypertension in a preclinical model of preeclampsia

• Main Authors: Jeremy W. Duncan (Author), Daniel Azubuike (Author), George W. Booz (Author), Brandon Fisher (Author), Jan M. Williams (Author), Fan Fan (Author), Tarek Ibrahim (Author), Babbette LaMarca (Author), Mark W. Cunningham (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction:Women with preeclampsia (PE) and reduced uterine perfusion pressure (RUPP) pre-clinical rat model of PE have elevated angiotensin II type 1 receptor agonistic autoantibodies (AT1-AA) and cerebrovascular dysfunction. Methods:Sprague Dawley rats had RUPP surgery with/without AT1-AA inhibi...