Angiotensin II type 1 receptor autoantibody blockade improves cerebral blood flow autoregulation and hypertension in a preclinical model of preeclampsia

• Главные авторы: Jeremy W. Duncan (Автор), Daniel Azubuike (Автор), George W. Booz (Автор), Brandon Fisher (Автор), Jan M. Williams (Автор), Fan Fan (Автор), Tarek Ibrahim (Автор), Babbette LaMarca (Автор), Mark W. Cunningham (Автор)
• Формат: ‌
• Опубликовано: Taylor & Francis Group, 2020-10-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Introduction:Women with preeclampsia (PE) and reduced uterine perfusion pressure (RUPP) pre-clinical rat model of PE have elevated angiotensin II type 1 receptor agonistic autoantibodies (AT1-AA) and cerebrovascular dysfunction. Methods:Sprague Dawley rats had RUPP surgery with/without AT1-AA inhibi...