Neuritogenic Activity of Trichostatin A in Adult Rat Retinal Ganglion Cells Through Acetylation of Histone H3 Lysine 9 and RARβ Induction

• Main Authors: Yoshiki Koriyama (Author), Kayo Sugitani (Author), Kazuhiro Ogai (Author), Satoru Kato (Author)
• Formato: Libro
• Publicado: Elsevier, 2014-01-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Abstract.: Like other CNS neurons, mature retinal ganglion cells (RGCs) cannot regenerate their axons after nerve injury due to loss of regenerative capacity. One of the reasons why they lose their capacity seems to be a dramatic shift in gene expression of RGCs under epigenetic modulation. In here,...