Functional heterogeneity of cancer-associated fibroblasts with distinct neoadjuvant immunotherapy plus chemotherapy response in esophageal squamous cell carcinoma

• Main Authors: Jun Jiang (Author), Chao Xu (Author), Donghui Han (Author), Yuan Lu (Author), Fa Yang (Author), Jiawei Wang (Author), Xiaolong Yan (Author), Xiaorong Mu (Author), Jipeng Zhang (Author), Chenghui Jia (Author), Xinyao Xu (Author), Kui Liu (Author), Zhenhua Liu (Author), Li Gong (Author), Yi Wan (Author), Qiang Lu (Author)
• Format: Book
• Published: BMC, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Novel neoadjuvant immunotherapy combined with chemotherapy (neoICT) has improved outcomes for patients with esophageal squamous-cell carcinoma (ESCC), but challenges persist in low response rates and therapy resistance. Little is known about the intra-tumoral heterogeneity in the ESCC tumor...